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Coenzymes, Enzymes And Enzyme Substrates

Leading Wholesaler of beta-nicotinamide mononucleotide (beta-nmn) (cas number: 1094-61-7), phenylphosphate disodium salt dihydrate (cas number: 66778-08-3), p-nitrophenylphosphate disodium salt hexahydrate (pnpp) (cas number: 333338-18-4), iptg (cas number: 367-93-1), sodium pyruvate (cas number: 113-24-6) and alpha-ketoglutaric acid (cas number: 328-50-7) from Mumbai.
Beta-Nicotinamide Mononucleotide (Beta-NMN) (CAS Number: 1094-61-7)

Beta-Nicotinamide Mononucleotide (Beta-NMN) (CAS Number: 1094-61-7)

Rs 1,000  / KgGet Best Price

Minimum Order Quantity: 1 Kg

Physical StatePowder
Packaging Size1 kg / 5 kg / 10 kg / 25 kg
ColorWhite
Packaging TypeBottle / Drum
CAS Number1094-61-7
Molecular Weight334.22
Purity.>95%
Empirical Formula (Hill Notation):C11H15N2O8P
Synonym(s): β-NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate, β-Nicotinamide ribose monophosphate, NMN

General description:
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.

Application:
β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.


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Phenylphosphate Disodium Salt Dihydrate (CAS Number: 66778-08-3)

Phenylphosphate Disodium Salt Dihydrate (CAS Number: 66778-08-3)

Rs 1,000  / KgGet Best Price
Physical StatePowder
Packaging Size1 kg / 5 kg / 10 kg / 25 kg
Packaging TypeBottle / Drum
CAS Number66778-08-3
Molecular Weight254.09
Linear FormulaC6H5PO4Na2 . 2H2O
Assay>98%

Synonym: Disodium phenyl phosphate dihydrate, Phenyl phosphate disodium salt


Suitable for Detection of Phosphates in milk.

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P-Nitrophenylphosphate Disodium Salt Hexahydrate (PNPP) (CAS Number: 333338-18-4)

P-Nitrophenylphosphate Disodium Salt Hexahydrate (PNPP) (CAS Number: 333338-18-4)

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Physical StatePowder
ColorWhite to Pale Yellow
Packaging Size1 kg / 5 kg / 10 kg / 25 kg
Packaging TypeBottle / Drum
CAS Number333338-18-4
Molecular Weight371.14
Purity>99%
Linear FormulaO2NC6H4OP(O)(ONa)2 . 6H2O

Synonym: p-Nitrophenyl phosphate disodium hexahydrate, Disodium 4-nitrophenyl phosphate hexahydrate, di-Sodium 4-nitrophenyl phosphate, pNPP disodium hexahydrate


Application : 

4-Nitrophenyl phosphate disodium salt hexahydrate has been used:
• as a component in diethanolamine buffer to detect alkaline phosphatase-conjugated antibodies in enzyme linked immunosorbent assay (ELISA)
• to treat adherent cells in adhesion assay
• as a phosphatase substrate in in vitro phosphatase assay in substrate buffer for ELISA
• as a substrate to measure the kinetic parameters of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase activity
• as substrate to assay acid phosphatase activity
• as substrate to assay bound antibodies with anti-rabbit/human alkaline phosphatase conjugate

Chromogenic substrate for the determination of acid and alkaline phosphatases.  The reaction produces a soluble end product that is yellow in color. The reaction may be stopped with 3 N NaOH and read at 405 nm.


Biochem/physiol Actions : 

p-Nitrophenyl phosphate (pNPP) is the substrate of choice for use with alkaline phosphatase in enzyme linked immunosorbent assay (ELISA) procedures. It is the substrate of choice in alkaline phosphatase systems due to its high sensitivity. This substrate produces a soluble end product that is yellow in color and can be read spectrophotometrically at 405 nm. This product is tested for use in cell culture applications. 4-nitrophenyl phosphate (pNPP), a small-molecule substrate can be used to study on alkaline phosphatases, acid phosphatases etc.

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IPTG (CAS Number: 367-93-1)

IPTG (CAS Number: 367-93-1)

Rs 1,000  / KgGet Best Price
Packaging Size1 kg / 5 kg / 10 kg / 25 kg
Packaging TypeBottle / Drum
CAS Number367-93-1
Purity>99%
Molecular Weight238.30
Empirical Formula (Hill Notation)C9H18O5S

Synonym: IPTG, Isopropyl β-D-1-thiogalactopyranoside, Isopropyl β-D-thiogalactoside


Isopropyl β-d-1-thiogalactopyranoside (IPTG) is a molecular biology reagent. This compound is a molecular mimic of allolactose, a lactose metabolite that triggers transcription of the lac operon, and it is therefore used to induce protein expression where the gene is under the control of the lac operator.

Therefore, its concentration remains constant during an experiment. For induction, a sterile, filtered 1 M solution of IPTG is typically added by 1:1000 dilution into an exponentially growing bacterial culture, to give a final concentration of 1 mM. However, different concentrations of IPTG may also be used.

Application : 
IPTG is commonly used in cloning procedures that require induction of β-galactosidase activity. It is used in conjunction with X-Gal or Bluo-Gal in blue-white selection of recombinant bacterial colonies that induce expression of the lac operon in Escherichia coli. IPTG functions by binding to the lacI repressor and altering its conformation, which prevents the repression of the β-galactosidase coding gene lacZ.

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Sodium Pyruvate (CAS Number: 113-24-6)

Sodium Pyruvate (CAS Number: 113-24-6)

Rs 1,000  / KgGet Best Price
Purity>99%
Physical StatePowder
ColorWhite
Packaging TypeBottle / Drum
Packaging Size1 kg / 5 kg / 10 kg / 25 kg
CAS Number113-24-6
Molecular Weight110.04
Linear FormulaCH3COCOONa

Synonym: α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt


General description : 

Sodium pyruvate (SP) is a simplest keto-acid. It crystallizes as very thin plates and belongs to the monoclinic system. Its utility in Knoevenagel condensation carried out in an aqueous medium has been examined. The standard molar enthalpy of formation and molar enthalpy of dissolution of SP at infinite dilution have been obtained. Its efficacy in treating mitochondrial DNA depletion syndromes has been investigated.

Application : 

Sodium pyruvate has been used:
• To prepare Bull Tyrode′s albumin-lactate-pyruvate diluent.
• In pyruvate tolerance test.
• To prepare oligodendrocyte culture medium.

Sodium pyruvate has been used as a component:
• of cutting solution for rat brain tissue slice preparation
• of M-199 medium for the maturation of oocytes
• of Krebs-Henseleit buffer for plasma incubation

Biochem/physiol Actions : 

Sodium pyruvate based therapeutic regimen is effective for treating mitochondrial diseases. It decreases tissue damage associated with the pathophysiology of brain damage, haemorrhagic shock and ischemia-reperfusion injury models.

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Alpha-Ketoglutaric Acid (CAS Number: 328-50-7)

Alpha-Ketoglutaric Acid (CAS Number: 328-50-7)

Rs 1,000  / KgGet Best Price
Physical StatePowder
Packaging Size1 kg / 5 kg / 10 kg / 25 kg
ColorWhite
Packaging TypeBottle / Drum
CAS Number328-50-7
Purity>99%
Molecular Weight146.10
Linear FormulaHOOCCH2CH2COCOOH
Synonym(s): 2-Oxoglutaric acid, alpha-Ketoglutaric acid, alpha-Ketoglutarate, 2-Oxopentanedioic acid

General description : 
α-Ketoglutaric acid is a 2-oxocarboxylic acid (2-OCA) that is formed as a metabolite in the Kreb′s cycle.
α-Ketoglutaric acid (2-oxoglutaric acid) is one of two ketone derivatives of glutaric acid. The term "ketoglutaric acid," when not further qualified, almost always refers to the alpha variant. β-Ketoglutaric acid varies only by the position of the ketone functional group, and is much less common.
Its carboxylate, α-ketoglutarate also called 2-oxoglutarate, is an important biological compound. It is the keto acid produced by deamination of glutamate, and is an intermediate in the Krebs cycle.

Application : 
α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline.

Other Notes : 
Reagent for the analysis of tryptophan; Substrate for glutamate dehydrogenase

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1-Naphthyl Phosphate Disodium Salt (CAS Number: 2183-17-7)

1-Naphthyl Phosphate Disodium Salt (CAS Number: 2183-17-7)

Rs 1,000  / GramGet Best Price

Minimum Order Quantity: 100 Gram

Packaging Size.100 gm / 500 gm / 1 kg / 5 kg
Packaging Type.Bottle
Physical State.Powder
Color.Off White
CAS Number.2183-17-7
Molecular Weight.268.11
Purity.>98%
Empirical Formula (Hill Notation).C10H7Na2O4P
Synonym(s): Disodium 1-naphthyl phosphate, α-Naphthyl phosphate disodium salt.

Application :
1-Naphthyl phosphate disodium salt has been used :
  • as a component in the mixture for soaking the chromatography paper for determining acid phosphatase activity
  • in the staining of the alkaline phosphatase isoforms in 7.5% non-denaturing polyacrylamide gel
  • as a component in the mixture for soaking the chromatography paper for preparing acid phosphomonoesterase-reactive imprinting sheets
  • as a component in the staining solution for staining the roots for determining phosphomonoesterase activity
  • Substrates:Substrate for determination of phosphatase.
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    5-Bromo-4-Chloro-3-Indolyl-Beta-D-Galactopyranoside (X-Gal) (CAS Number: 7240-90-6)

    5-Bromo-4-Chloro-3-Indolyl-Beta-D-Galactopyranoside (X-Gal) (CAS Number: 7240-90-6)

    Rs 1,000  / GramGet Best Price
    Physical StatePowder
    ColorWhite to Off White
    Purity>99%
    CAS Number7240-90-6
    Packaging TypeBottle
    Packaging Size10 gm / 25 gm / 100 gm / 500 gm / 1 kg / 5 kg
    Molecular Weight408.63
    Empirical Formula (Hill Notation)C14H15BrClNO6

    Synonym: 5-Bromo-4-chloro-3-indolyl β-D-galactoside, BCIG, X-Gal


    Application : 

    X-Gal is a chromogenic substrate for β-galactosidase that produces a rich blue color that can easily be detected visually over background. X-Gal is the substrate of choice for blue-white selection of recombinant bacterial colonies with the lac+ genotype.

    5-Bromo-4-chloro-3-indolyl β-D-galactopyranoside has been used to confirm transduction of Caki-2/LacZ clones. It has also been used in blue-white selection of transformants.

     

    X-Gal is a chromogenic substrate for β-galactosidase that produces a rich blue color that can easily be detected visually over background. X-Gal is the substrate of choice for blue-white selection of recombinant bacterial colonies with the lac+ genotype.

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    Beta-Nicotinamide Adenine Dinucleotide, Oxidized (Beta-NAD) (CAS Number: 53-84-9)

    Beta-Nicotinamide Adenine Dinucleotide, Oxidized (Beta-NAD) (CAS Number: 53-84-9)

    Rs 100  / GramGet Best Price
    Purity>95%
    Packaging Size100 gm / 500 gm / 1 kg / 5 kg
    Physical StatePowder
    Packaging TypeBottle
    ColorWhite to Off White
    Molecular Weight663.43 (anhydrous basis)
    CAS Number53-84-9
    Empirical Formula (Hill Notation)C21H27N7O14P2 . xH2O

    Synonym: β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide


    General description : 

    β-Nicotinamide adenine dinucleotide (β-NAD) is a ubiquitous biomolecule containing an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NADcomplexes, the enzyme-cofactor interactions are highly conserved.

    Application : 

    β-Nicotinamide adenine dinucleotide hydrate has been used as a supplement in chocolate agar plates for Haemophilus influenzae growth.

    β-Nicotinamide adenine dinucleotide hydrate has been used as a component of fibroblast cell culture media. It has also been used to study the viability of the cartilage constructs.

    β-Nicotinamide adenine dinucleotide hydrate was used as a test compound for studying the structure and electrochemical properties of NADH electrocatalysts.

    β-Nicotinamide adenine dinucleotide hydrate has been used:
    • to measure adenosine triphosphate (ATP) synthesis rates (kinetics measurements)
    • in the reaction buffer for pyruvate kinase (PK) activity assay
    • as a component of master mix for a high throughput screening
    • to prepare NAD+ standard solution for a study on NAD+ metabolomics
    • as a component of MurI assay reaction partial mixture for glutamate racemase reaction
    • as a component of a chromogenic staining solution to stain zebrafish embryo

    Biochem/physiol Actions : 

    β-Nicotinamide adenine dinucleotide (β-NAD) is an electron carrier and a cofactor, significantly involved in enzyme-catalyzed oxido-reduction processes and many genetic processes. NAD cycles between the oxidized (NAD+) and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth. NAD is also involved in microbial catabolism. β-NAD acts as a substrate for various enzymes in several cellular processes.

    Electron acceptor


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    Beta-Nicotinamide Adenine Dinucleotide, Reduced Disodium Salt (Beta-NADH) (CAS Number: 606-68-8)

    Beta-Nicotinamide Adenine Dinucleotide, Reduced Disodium Salt (Beta-NADH) (CAS Number: 606-68-8)

    Rs 1,000  / GramGet Best Price
    Packaging Size100 gm / 500 gm / 1 kg / 5 kg
    Physical StatePowder
    ColorWhite to Pale Yellow
    Packaging TypeBottle
    Purity>97%
    Molecular Weight709.40 (anhydrous basis)
    CAS Number606-68-8 (anhydrous)
    Empirical Formula (Hill Notation)C21H27N7Na2O14P2 . xH2O

    Synonym: β-DPNH, β-NADH, DPNH, Diphosphopyridine nucleotide, reduced form, NADH


    Application : 

    β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).

    As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations. 


    Biochem/physiol Actions : 

    NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
    As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

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    Beta-Nicotinamide Adenine Dinucleotide Phosphate Monosodium Salt (Beta-NADP-Na) (CAS No: 1184-16-3)

    Beta-Nicotinamide Adenine Dinucleotide Phosphate Monosodium Salt (Beta-NADP-Na) (CAS No: 1184-16-3)

    Rs 1,000  / GramGet Best Price
    Physical StatePowder
    Packaging Size100 gm / 500 gm / 1 kg / 5 kg
    ColorWhite to Pale Yellow
    Packaging TypeBottle
    Purity>98%
    Molecular Weight765.39
    CAS Number1184-16-3
    Linear FormulaC21H27N7O17P3 . Na

    Synonym: β-Nicotinamide-adenine Dinucleotide Phosphate, TPN, Co II, Na, NADP, Monosodium Salt

    General description : 

    A coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions (spectral ratio: 0.78-0.88 at 250/260 nm, pH 7.0; 0.16-0.26 at 280/260 nm, pH 7.0).

    A coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions.

    Spectra (pH 7.0): 250 nm/260 nm: 0.78-0.88; 280 nm/260 nm: 0.16-0.26.

    Application : 

    β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).


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    B-Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt (B-NADP-2Na) (CAS No: 24292-60-2)

    B-Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt (B-NADP-2Na) (CAS No: 24292-60-2)

    Rs 1,000  / GramGet Best Price

    Minimum Order Quantity: 100 Gram

    Physical StatePowder
    Packaging Size100 gm / 500 gm / 1 kg / 5 kg
    ColorWhite to Pale Yellow
    Packaging TypeBottle
    Purity>95%
    Molecular Weight787.37
    CAS Number24292-60-2
    Empirical Formula (Hill Notation)C21H26N7Na2O17P3

    Synonym: β-NADH phosphate disodium salt, β-NADP-Na2, Triphosphopyridine nucleotide disodium salt


    General description : 

    Nicotinamide adenine dinucleotide phosphate (NADP) and NADPH form a redox pair. The NADPH/NADP ratio regulates the intracellular redox potential, thereby influencing metabolic reactions in vivo.

    Application : 

    The β-NADH phosphate disodium salt has been used for the quantification of glucose in glycogen. It has also been used for the hexokinase assay.

    Nicotinamide adenine dinucleotide phosphate (NADP) and NADPH form a redox pair. NADP/NADPH is a coenzyme that supports redox reactions via the transport of electrons in a vast array of applications, especially anaerobic reactions such as lipid and nucleic acid synthesis. NADP/NADPH is a coenzyme couple in various cytochrome P450 systems and oxidase/reductase reaction systems, such as the thioredoxin reductase/thioredoxin system.

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    B-nicotinamide Adenine Dinucleotide Phosphate, Reduced (b-nadph) (cas Number: 2646-71-1)

    B-nicotinamide Adenine Dinucleotide Phosphate, Reduced (b-nadph) (cas Number: 2646-71-1)

    Rs 1,000  / GramGet Best Price

    Minimum Order Quantity: 10 Gram

    Packaging Size10 gm / 100 gm / 500 gm / 1 kg
    BrandInnovative
    Physical StatePowder
    ColorWhite to Pale Yellow
    Packaging TypeBottle
    Purity>97%
    Molecular Weight833.35 g/mol (anhydrous basis)
    CAS Number2646-71-1 (anhydrous)
    Empirical Formula (Hill Notation)C21H26N7Na4O17P3 . xH2O

    Synonym: β-NADPH, 2′-NADPH hydrate, Coenzyme II reduced tetrasodium salt, Dihydronicotinamide adenine dinucleotide phosphate tetrasodium salt, NADPH Na4, TPNH2 Na4, Triphosphopyridine nucleotide reduced tetrasodium salt

    Application : 

    β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

    Biochem/physiol Actions : 

    NADPH is an electron donor and a cofactor for many redox enzymes including nitric oxide synthetase.

    β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

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    1-Naphthyl Phosphate Monosodium Salt Monohydrate (CAS Number: 81012-89-7)

    1-Naphthyl Phosphate Monosodium Salt Monohydrate (CAS Number: 81012-89-7)

    Price on Request
    Packaging Size100 gm / 500 gm / 1 kg / 5 kg
    Packaging TypeBottle
    Physical State.Powder
    Color.White to Off White
    CAS Number.81012-89-7
    Molecular Weight.264.15
    Purity.>98%
    Linear FormulaC10H7OP(O)(OH)(ONa) H2O
    Synonym(s): Sodium 1-naphthyl phosphate monohydrate, α-Naphthyl phosphate monosodium salt monohydrate

    Application
     :
    1-Naphthyl phosphate monosodium salt monohydrate has been used as a non-specific phosphatase inhibitor in the splice correction assay in HeLa pLuc 705 cells.Preferred substrate for bioanalytical determinations of acid phosphatases, such as prostatic acid phosphatase.

    Biochem/physiol Actions :
    Non-specific phosphatase inhibitor. Inhibits acid, alkaline and protein phosphatases.

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    D-glucose-6-phosphate Disodium Salt (cas Number: 3671-99-6)

    D-glucose-6-phosphate Disodium Salt (cas Number: 3671-99-6)

    Price on Request
    Purity>99%
    Physical StatePowder
    ColorWhite
    Packaging TypeBottle
    Packaging Size100 gm / 1 kg / 5 kg / 10 kg
    CAS Number3671-99-6
    Molecular Weight304.10 (anhydrous basis)
    Empirical Formula (Hill Notation)C6H11Na2O9P . xH2O

    Synonym: G-6-P-Na2, Robison ester

    Biochem/physiol Actions : 

    D-Glucose 6-phosphate is the core carbohydrate substrate for the enzymatic synthesis of archaetidyl-myo-inositols produced through a pathway involving myo-inositol 1-phosphate synthase and CDP-archaeol.


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